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[95] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain

Richardson, President and CEO of the Campaign for Tobacco-Free Kids

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The US Centers for Disease Control and Prevention (CDC) states that among those who have experienced lung injuries with vaping, most patients report a history of using tetrahydrocannabinol (THC)-containing products. The CDC adds, Exclusive use of nicotine containing products has been reported by some patients with lung injury cases, and many patients with lung injury report combined use of THC- and nicotine-containing products. This was the first experimental design study that showed the damage caused by e-cigarettes say the researchers